Perlane is an excellent treatment for wrinkle correction, lip enhancement, smile lines and deep folds. Made of a natural substance called hyaluronic acid, it is a completely safe treatment. The hyaluronic acid in Perlane simply supplements the body's age-depleted hyaluronic acid to plump-up the lip or to raise the skin and "fill in" the particular wrinkle being treated. The difference between Restylane and Perlane is the size of the particle (with Perlane containing more hyaluronic acid). This means that Perlane does a better job of filling deep lines while Restylane is used in fine lines or in thin skinned people.